Regulators of regulatory pathway: Biofilm formation - Pseudomonas aeruginosa

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0202 experimental PXO_RS20535 T6SS00287 experimental protein Unknown Xanthomonas oryzae pv. oryzae PXO99A chromosome (NC_010717) 4488457..4488843 (-) 499576999 Unknown (↓)
REG0011 experimental Y880_05180 (rmsF) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 5147809..5148024 (-) 489186811 tssA1 expression (↑)
REG0041 experimental PA5183a (RsmN) T6SS00003 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5836470..5836685 (-) 554753081 FHA (PA0081) (↑); PA3487 (pldA) expression (↑)
REG0102 experimental VP_RS12395 (CsrA) T6SS00043 experimental; T6SS00044 experimental protein carbon storage regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2688313..2688510 (-) 490550575 Hcp and vgrG expression and secretion (↓)
REG0158 experimental PA14_52570 (RsmA) T6SS00150 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4660393..4660578 (-) 489176459 RSMF (↑); tssA1 RNA (↑); RSMA (↑)
REG0193 experimental YPK_3372 (CsrA) T6SS00260 experimental protein carbon storage regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3698608..3698793 (-) 169752121 YPK_3567 (RovC) (↑); YPK_3563 transcript (↑)
REG0100 experimental VP_RS12495 (barA) T6SS00043 experimental; T6SS00044 experimental protein TCS-HK Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2712492..2715290 (+) 491625032 Hcp expression and secretion (↓)
REG0150 experimental Psyr_3698 (gacS) T6SS00086 experimental protein TCS-HK Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4385550..4388303 (+) 499587812 T6SS transcription (↓)
REG0330 experimental Pchl3084_4333 (gacS) T6SS01266 insolico; T6SS01267 insolico protein TCS-RR Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 5113748..5116501 (+) 496335944 Pchl3084_3491 (gacA) (↓)
REG0351 experimental PSEBR_RS22825 (GacS) T6SS00431 insolico; T6SS00432 insolico protein TCS-RR Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome (NC_015379) 5188012..5190762 (+) 503459407 hcp1 transcript (↓); hcp2 transcript (↓)
REG0012 experimental Y880_02189 (gacA/uvrY) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS-RR Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 2199690..2200334 (-) 510933056 hcp expression (↓)
REG0044 experimental PA2586 (gacA) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 2925788..2926432 (-) 15597782 hcp1 (PA0085) expression and secretion (↓)
REG0091 experimental PFL_RS17995 (gacA/uvrY/SirA) T6SS00035 experimental protein TCS-RR Pseudomonas protegens Pf-5 chromosome (NC_004129) 4110513..4111154 (-) 499374263 T6SS transcripts (↓)
REG0101 experimental VP_RS09470 (UvrY) T6SS00043 experimental; T6SS00044 experimental protein TCS-RR Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2037468..2038112 (-) 491529158 CsrB (↓)
REG0253 experimental PAM18_RS12360 (gacA) T6SS00612 insolico; T6SS00613 insolico; T6SS00611 insolico protein TCS-RR Pseudomonas aeruginosa M18 chromosome (NC_017548) 2625815..2626459 (+) 489180874 hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓)
REG0331 experimental Pchl3084_3491 (gacA) T6SS01266 insolico; T6SS01267 insolico protein TCS-HK Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 4134794..4135435 (-) 496335231 Pchl3084_5419 (rsmY)promotor (↓); Pchl3084_1190 (rsmZ)promotor (↓); Pchl3084_1189 (rpoS)transcript (↓)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0074 experimental PP_4373 (FleQ) T6SS00014 experimental protein c-di-GMP regulatory pathway Pseudomonas putida KT2440 chromosome (NC_002947) 4963882..4965357 (-) 26991062 K1-T6SS (hcp1) expression (↑)
REG0161 experimental PA14_RS06615 (WspR) T6SS00150 experimental protein c-di-GMP regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1413158..1414201 (+) 489183089 Hcp1 production (↓)
REG0017 experimental SMDB11_2256 (TagF) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2380702..2381421 (+) 560174099 Unknown (↑)
REG0056 experimental PA0076 (TagF) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90844..91524 (-) 15595274 hcp1 (PA0086) secretion (↑)
REG0079 experimental Atu4331 (TagF-PppA) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1459258..1460673 (-) 159186120 Fha (Atu4335) (↑)
REG0264 experimental VEPGS_0621 (pppA) T6SS00793 experimental protein Tpp; QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) 23577..24245 (+) 225382187 Unknown (↑); T6SS1 transcript (↑); hcp1 transcript (↓)
REG0257 experimental VEPGS_0614 (PppA) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 15765..16880 (+) 225382180 LuxR (↓)
REG0043 experimental PA0074 (PpkA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 87000..90098 (-) 15595272 PA0081 (Fha-1/TagH) (↓)
REG0057 experimental PA0081 (Fha-1/TagH) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 98263..99756 (-) 15595279 Unknown (↓); clpV (↓)
REG0042 experimental PA0075 (PppA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90106..90834 (-) 15595273 PA0081 (Fha-1/TagH) (↑)
REG0092 experimental PFL_RS30815 (pppA) T6SS00035 experimental protein Tpp Pseudomonas protegens Pf-5 chromosome (NC_004129) 6902924..6903658 (-) 499376669 Hcp secretion (↑)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0166 experimental PA14_45960 (lasR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4085339..4086058 (-) 489173455 TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0168 experimental PA14_51380 (pqsE) T6SS00150 experimental; T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4566077..4566982 (-) 489176725 T6SS Transciption (↓)
REG0205 experimental NT01EI_RS04200 (EsrC) T6SS00346 experimental protein TCS regulatory pathway Edwardsiella ictaluri 93-146 chromosome (NC_012779) 933326..934018 (-) 737638726 T6SS translocon protein EvpC secretion (↓)
REG0054 experimental PA3974 (LadS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4453289..4455676 (-) 15599169 hcp1 (PA0085) expression and secretion (↓)
REG0151 experimental Psyr_4339 (ladS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5191591..5193585 (-) 639463044 T6SS transcription (↓)
REG0164 experimental PA14_RS05020 (LadS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1069280..1071716 (+) 15599169 Unknown
REG0053 experimental PA4856 (RetS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5452150..5454978 (+) 15600049 hcp1 (PA0085) expression and secretion (↑)
REG0152 experimental Psyr_4408 (retS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5270882..5273671 (+) 489494774 T6SS transcription (↑)
REG0165 experimental PA14_64230 (RetS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 5722815..5725643 (+) 489202068 Unknown
REG0076 experimental PP_0914 (BifA) T6SS00014 experimental protein c-di-GMP regulatory pathway Pseudomonas putida KT2440 chromosome (NC_002947) 1055990..1058071 (-) 26987650 the levels of c-di-GMP (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0202 experimental PXO_RS20535 T6SS00287 experimental protein Unknown Xanthomonas oryzae pv. oryzae PXO99A chromosome (NC_010717) 4488457..4488843 (-) 499576999 Unknown (↓)
REG0011 experimental Y880_05180 (rmsF) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 5147809..5148024 (-) 489186811 tssA1 expression (↑)
REG0041 experimental PA5183a (RsmN) T6SS00003 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5836470..5836685 (-) 554753081 FHA (PA0081) (↑); PA3487 (pldA) expression (↑)
REG0102 experimental VP_RS12395 (CsrA) T6SS00043 experimental; T6SS00044 experimental protein carbon storage regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2688313..2688510 (-) 490550575 Hcp and vgrG expression and secretion (↓)
REG0158 experimental PA14_52570 (RsmA) T6SS00150 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4660393..4660578 (-) 489176459 RSMF (↑); tssA1 RNA (↑); RSMA (↑)
REG0193 experimental YPK_3372 (CsrA) T6SS00260 experimental protein carbon storage regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3698608..3698793 (-) 169752121 YPK_3567 (RovC) (↑); YPK_3563 transcript (↑)
REG0100 experimental VP_RS12495 (barA) T6SS00043 experimental; T6SS00044 experimental protein TCS-HK Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2712492..2715290 (+) 491625032 Hcp expression and secretion (↓)
REG0150 experimental Psyr_3698 (gacS) T6SS00086 experimental protein TCS-HK Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4385550..4388303 (+) 499587812 T6SS transcription (↓)
REG0330 experimental Pchl3084_4333 (gacS) T6SS01266 insolico; T6SS01267 insolico protein TCS-RR Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 5113748..5116501 (+) 496335944 Pchl3084_3491 (gacA) (↓)
REG0351 experimental PSEBR_RS22825 (GacS) T6SS00431 insolico; T6SS00432 insolico protein TCS-RR Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome (NC_015379) 5188012..5190762 (+) 503459407 hcp1 transcript (↓); hcp2 transcript (↓)
REG0012 experimental Y880_02189 (gacA/uvrY) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS-RR Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 2199690..2200334 (-) 510933056 hcp expression (↓)
REG0044 experimental PA2586 (gacA) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 2925788..2926432 (-) 15597782 hcp1 (PA0085) expression and secretion (↓)
REG0091 experimental PFL_RS17995 (gacA/uvrY/SirA) T6SS00035 experimental protein TCS-RR Pseudomonas protegens Pf-5 chromosome (NC_004129) 4110513..4111154 (-) 499374263 T6SS transcripts (↓)
REG0101 experimental VP_RS09470 (UvrY) T6SS00043 experimental; T6SS00044 experimental protein TCS-RR Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2037468..2038112 (-) 491529158 CsrB (↓)
REG0253 experimental PAM18_RS12360 (gacA) T6SS00612 insolico; T6SS00613 insolico; T6SS00611 insolico protein TCS-RR Pseudomonas aeruginosa M18 chromosome (NC_017548) 2625815..2626459 (+) 489180874 hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓)
REG0331 experimental Pchl3084_3491 (gacA) T6SS01266 insolico; T6SS01267 insolico protein TCS-HK Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 4134794..4135435 (-) 496335231 Pchl3084_5419 (rsmY)promotor (↓); Pchl3084_1190 (rsmZ)promotor (↓); Pchl3084_1189 (rpoS)transcript (↓)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0074 experimental PP_4373 (FleQ) T6SS00014 experimental protein c-di-GMP regulatory pathway Pseudomonas putida KT2440 chromosome (NC_002947) 4963882..4965357 (-) 26991062 K1-T6SS (hcp1) expression (↑)
REG0161 experimental PA14_RS06615 (WspR) T6SS00150 experimental protein c-di-GMP regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1413158..1414201 (+) 489183089 Hcp1 production (↓)
REG0017 experimental SMDB11_2256 (TagF) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2380702..2381421 (+) 560174099 Unknown (↑)
REG0056 experimental PA0076 (TagF) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90844..91524 (-) 15595274 hcp1 (PA0086) secretion (↑)
REG0079 experimental Atu4331 (TagF-PppA) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1459258..1460673 (-) 159186120 Fha (Atu4335) (↑)
REG0264 experimental VEPGS_0621 (pppA) T6SS00793 experimental protein Tpp; QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) 23577..24245 (+) 225382187 Unknown (↑); T6SS1 transcript (↑); hcp1 transcript (↓)
REG0257 experimental VEPGS_0614 (PppA) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 15765..16880 (+) 225382180 LuxR (↓)
REG0043 experimental PA0074 (PpkA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 87000..90098 (-) 15595272 PA0081 (Fha-1/TagH) (↓)
REG0057 experimental PA0081 (Fha-1/TagH) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 98263..99756 (-) 15595279 Unknown (↓); clpV (↓)
REG0042 experimental PA0075 (PppA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90106..90834 (-) 15595273 PA0081 (Fha-1/TagH) (↑)
REG0092 experimental PFL_RS30815 (pppA) T6SS00035 experimental protein Tpp Pseudomonas protegens Pf-5 chromosome (NC_004129) 6902924..6903658 (-) 499376669 Hcp secretion (↑)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0065 experimental PA1430 (LasR) T6SS00004 experimental protein Global regulator; QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1558171..1558890 (+) 15596627 H2-T6SS promotor P (hsiA2) (↓)
REG0166 experimental PA14_45960 (lasR) T6SS00152 experimental; T6SS00151 experimental; T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4085339..4086058 (-) 489173455 TssA2 (PA14_43050) promotor (↓); HSI-III transcripts (↓); HSI-I transcripts (↑)
REG0168 experimental PA14_51380 (pqsE) T6SS00150 experimental; T6SS00152 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4566077..4566982 (-) 489176725 T6SS Transciption (↓)
REG0205 experimental NT01EI_RS04200 (EsrC) T6SS00346 experimental protein TCS regulatory pathway Edwardsiella ictaluri 93-146 chromosome (NC_012779) 933326..934018 (-) 737638726 T6SS translocon protein EvpC secretion (↓)
REG0054 experimental PA3974 (LadS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4453289..4455676 (-) 15599169 hcp1 (PA0085) expression and secretion (↓)
REG0151 experimental Psyr_4339 (ladS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5191591..5193585 (-) 639463044 T6SS transcription (↓)
REG0164 experimental PA14_RS05020 (LadS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 1069280..1071716 (+) 15599169 Unknown
REG0053 experimental PA4856 (RetS) T6SS00003 experimental protein Global regulator Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5452150..5454978 (+) 15600049 hcp1 (PA0085) expression and secretion (↑)
REG0152 experimental Psyr_4408 (retS) T6SS00086 experimental protein QS regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 5270882..5273671 (+) 489494774 T6SS transcription (↑)
REG0165 experimental PA14_64230 (RetS) T6SS00150 experimental protein QS regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 5722815..5725643 (+) 489202068 Unknown
REG0076 experimental PP_0914 (BifA) T6SS00014 experimental protein c-di-GMP regulatory pathway Pseudomonas putida KT2440 chromosome (NC_002947) 1055990..1058071 (-) 26987650 the levels of c-di-GMP (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)